Titus J Boggon Selected Research

Enzymes

11/2015	6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
2/2015	Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
11/2012	Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
12/2011	Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.

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Titus J Boggon Research Topics

Disease

34	Neoplasms (Cancer) 01/2022 - 06/2004
8	Central Nervous System Cavernous Hemangioma 01/2020 - 07/2010
7	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2010 - 06/2004
6	Melanoma (Melanoma, Malignant) 03/2014 - 09/2012
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 07/2006
5	Lung Neoplasms (Lung Cancer) 07/2012 - 06/2004
4	Leukemia 09/2014 - 10/2006
3	Craniosynostoses (Craniosynostosis) 01/2023 - 01/2019
3	Cerebral Cavernous Malformations 2 01/2020 - 05/2014
3	Carcinoma (Carcinomatosis) 11/2019 - 02/2013
2	Cerebral Cavernous Malformations 3 01/2020 - 05/2014
2	Hypoxia (Hypoxemia) 12/2011 - 12/2011
2	Adenocarcinoma of Lung 11/2007 - 06/2004
1	Neurodevelopmental Disorders 01/2023
1	Autistic Disorder (Autism) 01/2023
1	Liver Neoplasms (Liver Cancer) 01/2022
1	Inflammation (Inflammations) 01/2021
1	Agammaglobulinemia (Hypogammaglobulinemia) 01/2021
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 11/2019
1	Adenocarcinoma 11/2019
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 11/2019
1	Cardiomyopathies (Cardiomyopathy) 01/2019
1	Parkinson Disease (Parkinson's Disease) 01/2018
1	Carcinosarcoma 10/2016
1	Portal Hypertension 01/2016
1	Virus Diseases (Viral Diseases) 01/2016
1	Idiopathic Noncirrhotic Portal Hypertension 01/2016
1	Carcinogenesis 11/2015
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 04/2015
1	Seizures (Absence Seizure) 03/2015
1	Nervous System Diseases (Neurological Disorders) 03/2015
1	Hemorrhagic Stroke 03/2015

Drug/Important Bio-Agent (IBA)

13	Phosphotransferases (Kinase)IBA 01/2018 - 06/2004
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2009
6	Tyrosine (L-Tyrosine)FDA Link 09/2014 - 07/2006
6	Tyrosine Kinase InhibitorsIBA 10/2013 - 10/2007
6	ErbB Receptors (EGF Receptor)IBA 11/2009 - 06/2004
5	Epidermal Growth Factor (EGF)IBA 01/2022 - 02/2014
5	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2019 - 09/2004
5	Gefitinib (Iressa)FDA Link 04/2008 - 06/2004
4	EnzymesIBA 11/2015 - 12/2011
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2013 - 06/2004
4	Erlotinib Hydrochloride (CP 358,774)FDA Link 07/2012 - 10/2007
3	Small Interfering RNA (siRNA)IBA 02/2015 - 11/2012
3	LigandsIBA 01/2015 - 07/2012
3	Serine (L-Serine)FDA Link 08/2014 - 09/2012
2	ChromatinIBA 01/2023 - 01/2021
2	ras ProteinsIBA 01/2022 - 01/2013
2	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 01/2018
2	PlatinumIBA 01/2021 - 01/2018
2	lestaurtinibIBA 01/2021 - 01/2018
2	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2021 - 01/2019
2	DNA (Deoxyribonucleic Acid)IBA 11/2019 - 02/2013
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018 - 08/2015
2	AcetyltransferasesIBA 12/2016 - 02/2014
2	Phosphogluconate Dehydrogenase (Dehydrogenase, Phosphogluconate)IBA 11/2015 - 08/2014
2	Lysine (L-Lysine)FDA Link 08/2014 - 02/2014
2	Pyruvic Acid (Pyruvate)IBA 08/2014 - 12/2011
2	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 08/2014 - 12/2011
2	Glucose (Dextrose)FDA LinkGeneric 08/2014 - 11/2009
2	NucleotidesIBA 02/2013 - 01/2013
2	Peptides (Polypeptides)IBA 01/2013 - 10/2007
2	Phosphoglycerate Mutase (Phosphoglyceromutase)IBA 01/2013 - 11/2012
2	3-phosphoglycerate (glycerate 3-phosphate)IBA 01/2013 - 11/2012
2	2-phosphoglycerate (glycerate 2-phosphate)IBA 01/2013 - 11/2012
2	Lactic Acid (Lactate)FDA LinkGeneric 12/2011 - 11/2009
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2023
1	Transcription Factors (Transcription Factor)IBA 01/2023
1	rho GTPase-activating proteinIBA 01/2022
1	p120 GTPase Activating ProteinIBA 01/2022
1	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 01/2022
1	alpha-hydroxyglutarateIBA 01/2021
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021
1	EuchromatinIBA 01/2021
1	neratinibIBA 11/2019
1	Cytidine DeaminaseIBA 11/2019
1	copanlisibIBA 11/2019
1	AfatinibIBA 11/2019
1	integrin-linked kinaseIBA 01/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2018
1	Acetyl-CoA C-Acetyltransferase (Acetyl Coenzyme A Acetyltransferase)IBA 12/2016
1	Histones (Histone)IBA 10/2016
1	Nucleosomes (Nucleosome)IBA 10/2016
1	NucleosidesIBA 01/2016
1	deoxyguanosine kinaseIBA 01/2016
1	Didanosine (Videx)FDA LinkGeneric 01/2016
1	physcioneIBA 11/2015
1	RNA (Ribonucleic Acid)IBA 11/2015
1	Octamer Transcription Factor-1IBA 08/2015
1	acetoacetic acid (acetoacetate)IBA 08/2015
1	Glutamate DehydrogenaseIBA 02/2015
1	Glutathione Peroxidase GPX1IBA 02/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2015
1	Ketoglutaric Acids (Ketoglutaric Acid)IBA 02/2015
1	AntioxidantsIBA 02/2015
1	FumaratesIBA 02/2015

Therapy/Procedure

5	Therapeutics 11/2019 - 06/2004
2	Sutures (Suture) 01/2023 - 01/2019
1	Drug Therapy (Chemotherapy) 01/2021